Ozempic side effects and how long does it last

Introduction: Ozempic side effects and how long does it last. Ozempic is a medicine used to cure type 2 diabetes. Its active ingredient is semaglutide, which belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. Ozempic works by imitating the actions of a naturally happening hormone called GLP-1.

This hormone helps regulate blood sugar levels, promote weight loss, and reduce appetite. While Ozempic can be an effective treatment for many people with type 2 diabetes, it can have side effects like all medications.

Some side effects occurred more frequently in those who took the 1 mg dose of Ozempic than in those who took the 0.5 mg dose, suggesting that the side effects are dose-dependent.

For example, nausea occurred in 15.8 percent of people at the 0.5 mg dose, compared to 20.3 percent of people taking the 1 mg dose. People who experienced Ozempic weight loss side effects lost an average of 9.3 to 14.1 pounds during the 40 weeks on Ozempic.

In this article, we will explore the side effects of Ozempic, their duration, and how to manage them.

Ozempic side effects and how long does it last
Ozempic side effects and how long does it last 2

Ozempic and Type 2 Diabetes

Before delving into the side effects of Ozempic, let’s first understand its role in managing type 2 diabetes. Type 2 diabetes is a chronic condition characterized by high blood sugar levels (hyperglycemia) due to the body’s inability to use or produce enough insulin.

Insulin is a hormone that helps regulate blood sugar by allowing glucose to enter cells for energy. People with type 2 diabetes often require medications to manage their condition and lifestyle changes like diet and exercise.

Ozempic, as mentioned earlier, is a GLP-1 receptor agonist. It helps lower blood sugar levels in several ways:

Increasing Insulin Release: Ozempic stimulates the pancreas to release more insulin when blood sugar is elevated.

Inhibiting Glucagon Release: It reduces the release of glucagon, a hormone that raises blood sugar levels.

Slowing Gastric Emptying: Ozempic slows down the rate at which the stomach empties, which can help control post-meal blood sugar spikes.

Promoting Weight Loss: Many people with type 2 diabetes are overweight or obese. Ozempic can lead to weight loss by decreasing appetite and increasing feelings of fullness.

Cardiovascular Benefits: Studies have shown that Ozempic can reduce the risk of major cardiovascular events in people with type 2 diabetes who have a high risk of heart disease.

Now that we understand how Ozempic works, let’s explore the potential side effects of this medication.

Common Side Effects of Ozempic

Like any medication, Ozempic may cause side effects. It’s important to note that not everyone will experience these side effects, and many people tolerate the drug well. Common side effects of Ozempic include:


One of the most frequently reported side effects of Ozempic is nausea. Some people may experience mild to moderate nausea, especially when taking the medication. This side effect can often be managed by taking Ozempic with a meal.


In some cases, nausea may lead to vomiting. If you experience persistent vomiting, contact your healthcare provider. They can guide how to manage this side effect.


Diarrhea is another digestive side effect that some people may experience. Staying hydrated and consuming a balanced diet can help alleviate this symptom.


While diarrhea is a possible side effect, some individuals may also experience constipation. Drinking plenty of water and including fiber can help prevent or relieve constipation.

Abdominal Pain

Abdominal discomfort or pain may occur, particularly during the initial weeks of Ozempic treatment. It frequently subsides as your body adjusts to the medication.

Decreased Appetite

A reduced appetite is a common effect of Ozempic, which can benefit those looking to lose weight. However, consult your healthcare provider if it leads to significant weight loss or makes it difficult to maintain a balanced diet.

Injection Site Reactions

Ozempic is administered as a subcutaneous injection. Some individuals may encounter injection site reactions, such as redness, itching, or swelling. These reactions are usually gentle and temporary.


Hypoglycemia, or low blood sugar, is a potential side effect of Ozempic, mainly when combined with other blood sugar-lowering medications.

Symptoms of hypoglycemia may include shakiness, sweating, confusion, and rapid heartbeat. It’s essential to be aware of these symptoms and take appropriate action, such as consuming glucose or a sugary snack if they occur.


Although rare, reports of pancreatitis (pancreas inflammation) have been associated with Ozempic use. Symptoms of pancreatitis include severe abdominal pain that may release to the back, nausea, and vomiting. If you experience these signs, seek medical attention instantly.

Thyroid Tumors

Animal studies show a slight increase in the risk of thyroid tumors associated with Ozempic. It’s important to discuss any thyroid-related concerns with your healthcare provider.

Duration of Side Effects

The period of Ozempic side effects can vary from person to person. Some side effects, like nausea and vomiting, often occur during the initial weeks of treatment and tend to improve as the body adjusts to the medication. Others, such as a decreased appetite and weight loss, may persist as long as you take Ozempic.

It’s crucial to recognize that not everyone will experience these side effects; some individuals may have no adverse effects. Additionally, the intensity and duration of side effects can be influenced by your physiology, dosage, and how well you adhere to your healthcare provider’s instructions.

Effects of long-term use of Ozempic

Some people may experience chronic side effects from taking Ozempic, mainly gastrointestinal effects. At least 10% of patients who start Ozempic or Wegovy must stop taking the drug because side effects do not improve.

For some people, nausea and vomiting can lead to nutrient deficiencies or malnourishment. These side effects can also affect mood and energy levels.

Some evidence suggests that Ozempic may lead to suicidal thoughts. In July 2023, the European Medicines Agency announced that it would investigate reports of suicidal thoughts and self-harm in people taking liraglutide and liraglutide medicines such as Ozempic, Vigovi, and Saxenda.

Rapid weight loss from Ozempic can lead to sagging, loose skin all over the body, a phenomenon known on the Internet as “Ozempic face.” Weight loss can lead to facial fat loss, making the face look older or weaker.

Managing Side Effects

If you experience side effects while taking Ozempic, here are some strategies to help manage them:

Nausea and Vomiting: Taking Ozempic with a meal can help reduce nausea. If vomiting occurs, contact your healthcare provider for guidance.

Diarrhea and Constipation: Staying hydrated and maintaining a balanced diet with adequate fiber can help alleviate gastrointestinal symptoms.

Abdominal Pain: If you experience abdominal discomfort, it often subsides as your body gets used to the medication. However, consult your healthcare provider if the pain is severe or persistent.

Decreased Appetite: Discuss with your healthcare provider if a reduced appetite leads to unintended weight loss or nutritional concerns. They may adjust your treatment plan.

Injection Site Reactions: Proper injection technique and rotating injection sites can minimize discomfort at the injection site.

Hypoglycemia: Be vigilant for signs of low blood sugar and keep a source of quick-acting glucose on hand. Confirm your healthcare provider is aware of your symptoms.

Pancreatitis: If you experience severe abdominal pain, nausea, or vomiting, seek immediate medical attention, as these could be symptoms of pancreatitis.

How long do the side effects last?

Mild, typical side effects usually go away after a few days, although some may last for a few weeks. In rare cases, the side effects of Ozempic may not go away. Talk to your healthcare provider if side effects are bothersome or last for months.

After stopping Ozempic, the drug may take a few weeks to leave the body, especially at the highest dose of 2 mg. In clinical trials, it took about five weeks after the last amount. Therefore, you may experience side effects even after stopping the drug.

When to Contact Your Healthcare Provider

Maintaining open communication with your healthcare provider while taking Ozempic is essential. Contact them if you experience any of the following:

  • Severe or persistent side effects
  • Signs of hypoglycemia that are difficult to manage
  • Symptoms of pancreatitis
  • Significant changes in weight or appetite
  • Any new or unusual signs that concern you

Conclusion: Ozempic side effects and how long does it last

Ozempic (semaglutide) is a prescription drug used to treat high glucose (blood sugar) levels in people with type 2 diabetes, along with a healthy diet and increased activity. It is also approved to reduce the risk of major adverse cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes and known heart disease.

Common side effects, such as stomach-related nausea, vomiting, or diarrhea, may occur but are mild and transient, improving after several weeks of treatment. If you develop swelling in your neck, a lump, hoarseness, difficulty swallowing, or difficulty breathing, see your doctor immediately.

These symptoms can be a sign of thyroid problems. You should see a doctor about Ozempic side effects if they persist and are bothersome or if you are having a severe allergic reaction.

Allergic reactions, especially if you have trouble breathing, are medical emergencies. Ozempic can also cause side effects that are a sign of a more severe problem that requires medical attention.

Also read: Side Effects of Ibrance; Side effect of Dupixent; Side Effects of Olumiant

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