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Triple-negative breast cancer

Triple-negative breast cancer: prognosis, management, survival rate, diet, treatment, vaccine. Introduction.Triple breast cancer is the most aggressive and dangerous type of breast cancer because it starts to spread all over the body quickly whenever it is found.

Triple-negative breast cancer: prognosis, management, survival rate, diet, treatment, vaccine
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Triple-negative breast cancer: prognosis, management, survival rate, diet, treatment, vaccine

Triple-negative breast cancer is progesterone receptor negative, HER2 negative and estrogen receptor-negative. It means that breast cancer cells don’t have estrogen and progesterone receptor hormones, and cancer cells don’t make enough HER2 protein. 

Triple-negative breast cancer doesn’t reply or respond to hormonal therapy medicines, and the same is the case with the HER2 protein. It is the most aggressive form of breast cancer as it is harder to treat and comes back after treatment quickly. Triple-negative breast cancer does not have any breast receptor cells in another type of breast cancer cell.

About 10-15% is triple-negative breast cancer among all the types of breast cancer. Some specific women are affected with triple-negative breast cancer. The woman younger than 40 years is influenced mainly by triple-negative breast cancer. The woman of black color is primarily affected by it. A woman who has BRCA1 mutations has great chances of triple-negative breast cancer.

Symptoms of triple-negative breast cancer

The symptoms of triple-negative breast cancer are like other common breast cancer symptoms. Some symptoms are less dangerous, so it is not considered breast cancer. Here I will tell you some signs by which you can diagnose whether it is triple-negative breast cancer.

  • Swelling in all parts of the breast and new mass or lymph at the breast
  • Hollow or dig skin
  • Pain in the breast or at the nipples
  • The leakage from the breast that is not breast milk
  • Denial of nipples when your nipples pinch inwards
  • Thickening or reddish on breast
  • It is swollen with lymph nodes. These all are the common symptoms of triple-negative breast cancer.

Prognosis

Triple-negative breast cancer may occur in the younger Black, African American woman and the non-Hispanic Black, and triple breast cancer is the poor prognosis of all the breast cancers. Its survival rates are severe as it is aggressive and dangerous. African women have poorer survival chances from triple-negative breast cancer than white women.

If you treat triple-negative breast cancer, good treatment results depend upon many factors. Chemotherapy can create a difference in the outcome. If you can find the size of the invasive part of the tumor and the number of lymph nodes, these two things can affect your prognosis. 

But if unfortunately, cancer spreads all around, you cannot find out the number of lymph nodes to prove a less specific prognosis. After this scary diagnosis, there is the hope of survival, and hope is essential in that aggressive disease. 

Uses of chemo may prove stressful and scary, but your positive thinking can make a difference in your survival rate. When you think positively and feel that you are getting well, you will get cured by triple-negative breast cancer. As thinking can affect your survival rates, cure hormones will start to produce in your body when you think you are getting well. Believe so optimistically about your health.

 As recent progress helps identify new treatments, this improves the prognosis for triple-negative breast cancer. Also, many new ways are found to use existing treatment, and this search can make the earlier treatment more effective. Diagnoses are made first for treatment of cancers; now, the same case is with triple-negative breast cancer; before its treatment, it is first diagnosed, and then treatment is started.

Triple-negative breast cancer management

15% of breast cancer consists of triple-negative breast cancer, and it becomes difficult to manage it at the lethal stage. These cells do not contain estrogen or progesterone receptors with none or too little HER2 protein. With the lack of this protein, hormone therapy that targets HER2 is not helpful. That’s why most people go to the chemotherapy treatment option.

Survival rates of triple-negative breast cancer

The survival rates of triple-negative breast cancer are less than other forms of breast cancer due to its aggressive and dangerous nature. About 77 % of women with triple-negative breast cancers survived five years after their diagnosis. 

Here are many people who lived more than five years after their diagnosis. Among these people, 97 % lived more than ten years, and about 95% had a life span of 15 years after their diagnosis. Survival rates may vary in different people according to situations and care.

The survival rate in any person depends upon the grade of cancer in that person, and also factors can change the survival rates. Clinical stages and LVI are the only prognostic factors that can tell about the survival rates. Chemotherapy and the extent of surgery do not affect the triple-negative breast cancers outcomes. 

If negative breast cancer does not spread in all parts of the breast, then the survival rates of that person are about 91 per cent. According to Americans, the person with triple-negative breast cancer has roughly a 75 percent survival rate. 

The survival rate is the rate at which one group of people is diagnosed in a limited time with the same age as other people without cancer. Your survival rate can be found according to your age, health, and cancer grade.

Diet of triple-negative breast cancer

There are no scientifically diet recommendations for triple-negative breast cancer. But it is scientifically proven that most people die due to the following things. Poor diet, physical inactivity, uses of alcohol and being overweight are significant reasons for the death of many people.

According to ACS recommendations, following a diet can help your health improve. Uses of mixed vegetables, fruits, grains and fibers rich legumes can improve anyone’s health from any disease.

Also, doctors or ACS prohibited you by using red meat, long proceeded cooked food and drinks made with sugar.ACS recommend you not to drink alcohol.

Polyphenols, the compound of plenty of plants, effectively cure triple-negative breast cancer. In olive oil, tea and grapes, these compounds are found in plenty of amounts. In soy products, the Isoflavones are regarded as reducing triple breast cancer. Triple breast cancer is found more in women who use eggs and meat.

While the risk of triple-negative breast cancer is less in that woman who uses seafood and vegetables, the chances of triple-negative breast cancer are in that woman who has thick breast due to diet problems compared to that woman with thin breast.

In the 2019 research, it is mentioned that triple-negative breast cancer is in the woman who uses food with a lot of fructose. However, more researchers are working for the proper reason for breast cancer.

Treatment of Triple-negative breast cancer

It is treated with surgery, chemotherapy and radiation. There are the following ways of treatment of Triple-negative breast cancer.

Chemotherapy

Chemotherapy is the most common and best way to downstage tumors, make them less aggressive and shrink tumors.

Chemotherapy is the medicine used to kill the cancer cells in the breast. Chemo can shrink the cancerous cells in your body. This medicine is injected into your body through needles, veins or pills. A doctor can use chemo in three different ways.

Neoadjuvant therapy

It is a type of chemotherapy that shrinks cancer cells and makes the operation easier, and this chemo is used before procedures. If you have breast cancer, but your doctor thinks they cannot operate yet, they will prefer you to use these chemos. If your doctors believe they cannot save you from breast cancer, this therapy is done.

Adjuvant therapy can be used after surgery; if you notice that you have large tumor cells, then you can use this therapy. Immunotherapy is used with chemo when the cancer spreads in all body parts and chances of survival are minor. And it can be used after surgery where your doctor told you that they could not operate on you.

As triple-negative breast cancer is aggressive, mastectomy is used to remove the entire breast from the body. If you have several tumors or pain in the nipples, the tumor is large or already tumors in your breast, then you can use mastectomy.

Radiations

Radiations are used after surgery on your skin to kill the remaining cancer cells with radiation. There are a lot of chances that tumors come back to stop their radiation and are used to kill the entire cancer cells. But continuous searches are done on the proper treatment of cancer cells. Doctors have new medicines that are rare for breast cancer treatment.

Triple-negative breast cancer vaccine

The vaccine for cancer is a great option that boosts the ability to remove and eradicate tumor cells, but it doesn’t have significant benefits. There are great chances to apply vaccines with anti-HER2 monoclonal antibodies. The famous leading vaccine is the 3.1 Types of Breast Cancer Vaccine.

Nowadays, the most common vaccine used for breast cancer is peptides extracted from tumor antigens. There is also some critical Vaccination of tumor antigen-related carbohydrates and protein that were discovered a long time ago. The vaccine is mainly used for young women and girls and also on the way to use for boys. The HPV vaccines also benefit ladies and men who have breast cancer.

Read also: Stage 4 breast cancer

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