Health definition

Histopathology definition meaning

Histopathology definition meaning. Different branches of science help to diagnose different kinds of diseases, and one rapidly growing spectrum is histopathology.

The term histopathology is related to the study of tissues and diseases. Various laboratories, companies, and organizations are working in this field and introducing new techniques for diagnosis and making progressive changes.

They use different ways to diagnose; for example, they use histopathology images for diagnosis because, in this way, they can better diagnose the disease and suggest something best for this disease. But ordinary people are not familiar with this term, so if they learn about histopathology, in this article, we will talk all about histopathology.

Histopathology definition, meaning, concept
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Histopathology definition, meaning, concept

What is histopathology?

Histopathology is a study that aids in the diagnosis of tissue-related diseases. This study includes properly examining tissues under the microscope to know the reason and stage or level of diseases. In addition, this study helps the doctors to manage the patient’s care.

Uses of histopathology

Histopathology helps to diagnose various tissue and cell-related diseases such as

  • immunotoxicity

Histopathology helps to diagnose immunotoxicity; it is a disease in which the immune system does not work properly due to adverse effects of harmful substances and blood acidity level increases. According to study, the histopathology is also effective for the diagnosis of immunotoxicity

  • Cancer

The histopathologist diagnoses cancer by examining the tissues or cells of the targeted area. First, they take tissue or cells from lumps and bumps of the target area and examine it under a microscope to identify the cause of abnormality of tissues or cells.

If they find it malignant, then they try to find the type of cancer and its stage. And they try to provide help to patients in their treatment.

  • Viral infection

Different types of viruses cause different diseases, and these viruses cause morphological changes, and they form inclusion bodies in it and few viruses from various cells in bodies.

Therefore, Histopathologic uses different forms of strains such as Giemsa stain, seller stain for diagnosis of infection like herpesvirus, and cayo megalosaurus.

  • Fungal infection

Histopathology is still one of the primary methods of diagnosis in mycology. The primary advantages of histopathology include speed, efficiency, and the capability to offer an initial identification of the fungus that is infected as well as showing the reaction of tissue.

However, it provides crucial information prior to the fungus that can be identified in a mycology lab. Histopathology is also the only method of diagnosing diseases because L. Loboi or Rhinosporidium Seeber can be diagnosed with histopathology. Moreover, A variety of histologic stains are readily available that are used to identify fungi within tissue sections. 

While some are specific fungal stains, others are used more broadly and can be used to study the reaction of tissues or the fungus infecting the tissue. GMS Gridley’s fungus, a fungus that is GMS, and PAS are incredibly effective to show the organisms.

However, of these three, GMS has the most significant benefit because it can stain the non-viable and old fungi.

  • Bacterial infection

Bacteria are among the most challenging microorganisms to identify when examining routine H and E-stained. Nevertheless, histological sections pathology diagnosis is prevalent, and the staining techniques most commonly employed to detect the bacilli that are fast to acid in smears are ZN and Auramine. 

However The identification of tissue of a mycobacterial disease starts with a thorough examination of sections of tissue stained with H and E. While organisms are not visible, however, the pattern of granulomatous inflammation offers the first sign that mycobacteria are present.

Importance of histopathology

Histopathology is quite important to detect and know the details about the diseases and helps in finding the different treatments. Histology refers to the study of living tissues, and pathology means studying the changes caused by foreign agents and microorganisms to the organisms.

Working in the lab for many hours makes you understand things more precisely. 

Additionally Histopathology is used in different fields of life. Actually, it is an amalgam of two main fields: histology and pathology. 

Moreover, Thus Histopathology allows the identification of the changes that occurred in the normal living tissues and the agent microorganisms that can’t be seen with naked eyes.  But according to experts the importance of Histopathology is not entirely understood. 

The etymology of histopathology technique 

Histopathology started in 1838 when the first book of Histopathology “on the nature and structure characteristics of cancer” was published by Johannes miller. In 1951 the first compound microscope was formed, but it had many technical problems. In 1673 the manufacturing of a simple microscope with a single lens was started by Anton van Leeuwenhoek.

They had better magnification and resolution. The first microtome was manufactured in 1848. The Cambridge rocker was constructed in 1885, Minot in 1886, and the sled microtome was manufactured in 1910. In the mid-1800s, paraffin wax for infiltration and support during the sectioning was introduced. And formalin was used in 1893 for the first time.

In 1945, hand processing was replaced by automated tissue processors, In 1951 cryostats were manufactured. 

Moreover During the last 50 years, enzymes histochemistry, histopathology, and polarizing microscopy gained importance. In 1980 the diagnosis of cancer was revolutionized by the use of histopathology.

Services involved in histopathology

Histopathology is a complete study of tissues and root cause of tissue diseases, so it involves different services for better results; it includes the following techniques.

  • Necropsy
  • Sophisticated histological processing
  • Evolution by pathologist

Additionally, this includes other services such as

  • Frozen tissue processing and sectioning
  • Histochemical strain for cellular components
  • Plastic processing helps in thin selection support neuropathology and productive pathology.

Role of histopathologist

Histopathologists are trained doctor’s workers who work efficiently in the field of histopathology. First, the histopathologists examine the tissues or cells to know the damage and its causes. Then, they can diagnose the disease by a small piece of tissue of the skin, kidney, liver, and other organs; this term is known as a biopsy.

Moreover, the histopathology specialist can diagnose the illness or tissue changes just by seeing the images received from the examination. After the proper examination and diagnosis, their main purpose is to write a comprehensive report. 

Additionally, the histopathologists play an important role in writing reports on specimens, research reports, and teaching. They also work with patients to provide the services. In short, the histopathologists play an important role.


No doubt histopathology is the best way to diagnose different diseases such as cancer, viral infections, toxicity, bacterial infection, etc.

Additionally, the histopathologist examines tissue and cells and finds out the type and reason of the disease behind this. According to surveys, only doctors, expert workers can examine suspicious tissues and cells.

Read also in the blog: Vaccine definition meaning; How many sessions of reductive massages will show results?; Ontology in medicine and nursing

External resources: Rcpath; verywellhealth

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