Purines and uric acid

Introduction: Purines and uric acid. Purines are nitrogenous bases of DNA. It is a heterocyclic aromatic compound consisting of two fused rings. Basic purine’s structure consists of nine atoms. It has involved in the catabolism of uric acid.

Catabolism is the chemical breakdown of a substance. Break down of purines produce uric acid and has been found in some drinks and food. Uric acid dissolves in blood and travels to the kidney for purification.

Purines and uric acid
Purines and uric acid

It passes out of the body through urine. When it is not excreted, you can get sick. A disease called hypercupremia occurs due to excessive uric acid.

Purines and uric acid are heterocyclic compounds containing nitrogen and carbon. Purines have found in our body, and their chemical metabolism produces uric acid.

It passes to the kidney for publication and then removes through urine. High levels of purines lead to more uric acid production, which causes arthritis disease. Let’s learn more about Purines and uric acid.

Sources of purine

There are the following sources of high-purine food.

• Some rich sources include shellfish, cod fish, sea fish, and trout.

• While some meat like bacon, veal, and organ meat like liver are rich in it. 

Structure of purines 

Both purine and pyrimidine rings have one 6-members with two nitrogens and four carbons. These are not related through a metabolic pathway. Pathways for purine biosynthesis and degradation exist in all organisms.

The combination of sugar rings and purines has called nucleoside. A nucleotide structure consists of a sugar ring, Purines, and phosphoric Acid.

Function of purine 

Purine is an essential precursor for nucleic acid synthesis. But their function is not limited. These act as metabolic signals, provide energy, control cell growth, and are part of coenzyme.

It contributes to sugar transport and donates a phosphate group to phosphorylation reactions. Some purines seven a more specialized role in the central nervous system, not only in neurons but also in the glial cells.

Purine is vital to all living organisms. They are essential components for synthesizing nucleic acid, proteins, and other metabolites.

Structure of uric acid 

It is a white tasteless, odorless crystalline product of purine, found in blood and urine and seen in the body’s various organs.

It can form stones and crystals in different disease states. It is the combination of Carbon, Nitrogen, Hydrogen, and Oxygen.

When purine breaks, it includes uric acid. It has 168 atomic mass unit molecular weight and appears as a powder or solid white. You can find it in food materials.

Sources of uric acid 

It is the waste product that comes from the digestion of food. It contains purines. Purines are also found in high levels of beer, red meat, and organ meats. Your body filters uric acid in your kidneys and urine.

Your diet consumes too much purine, or you can not end this by-product fast. It can build up uric acid in your body. There are some reasons why collecting uric acid in your body, overweight, diet, and genetics.

Level of uric acid 

• An average level of uric acid is under 6.8mg

• A high level of uric acid is above 6.8mg. It can lead to a disease called painful joints that accumulate urine crystals.

Symptoms of high uric acid 

• Swelling 

• Redness 

• Joints misshapen 

• The Problem in moving affected joints 

• Joint stiffness


A disease management program can help stop high uric acid Levels and joint pain flare-ups. Your surgeon can prescribe medications that dissolve high uric acid crystals.

Some other ways enable you to manage a high level of it. It would be best if you tried to lose weight. Are they watching what you eat? Limit your food Intake of organs, fish, and red meat, and do not contain alcohol.

Relation between purines and uric acid  

Purines and uric acid are heterocyclic ring structures containing carbon and nitrogen atoms. Purines are the most common chemical compound on the planet. It has two kinds endogenous and exogenous.

Exogenous are those purines the body has absorbed through foods you eat. Endogenous absorbs the body itself. Your body digest and expels the purine without any difficulty. 

But, your digestive system cannot complete the process of purines. If you eat many purines in the usual routine, you will experience excess uric acid in your body. All cells must be adequate purines for their growth and survival. Enzymes control their synthesis and degradation. 

In humans, the final product of purines is uric acid. Uric acid undergoes that metabolic process and purification in the kidney. The enzyme Uricease converts the uric acid into allantois, passing out through urine.

High purine levels lead to a large amount of uric acid production, which causes Gout. It is a painful form of arthritis. A high level of uric acid in the blood causes hypercupremia.

Conversion of purine into uric acid 

Purine is an organic compound in many foods, including red meat and seafood. The breakdown of purine produced uric acid. Its conversion process is complex but easy to understand.

Purine breaks down into its two components and guanine during digestion. These two components pass through a series of enzymatic reactions, forming the compound xanthine.

It converts into uric acid through an enzyme xanthine oxidase, and then uric acid passes to the kidney and wolves through urine.

Conclusion: Purines and uric acid

Purine and uric acid are heterocyclic compounds that contain carbon and nitrogen. Purine sources food, meat, fish, and red meat. When the body breaks purines, it produces the waste product uric acid.

It dissolves into the blood and removes through urine. When the kidney can’t process uric acid, it accumulates in the body and causes health problems.

The accumulation of uric acid in body tissue and joints causes the raises Gout. It is painful information about joints. People who eat high-purine-rich food like seafood and red meat and consume alcohol develop Gout.

Genetics may also play a role in this disease. Purines form the DNA and RNA structure acting as nitrogenous bases. In short, purine and uric acid are vital in developing body structure and cellular processes.

Also read: Food to increase uric acid; High uric acid effects; Milk and uric acid

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